CD162 (PSGL-1) Mouse anti-Human, PE, Clone: FLEG, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-1629-42

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15566916

Quantity Price
1 £ 140.02 / 100 tests
Estimated Shipment date
from Supplier 05-05-2017
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Description and Specification

Specification

Concentration 5μL (0.06μg)/test
Host Species Mouse
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Clone FLEG
Antigen CD162 (PSGL-1)
Isotype IgG2a
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Species Reactivity Human
Conjugate PE
Monoclonal or Polyclonal Monoclonal
Primary or Secondary Primary
Regulatory Status RUO
Applications Flow Cytometry
Quantity 100 tests

This FLEG monoclonal antibody recognizes human CD162, which is also known as P-selectin glyocoprotein ligand-1 (PSGL-1). This 120kDa protein exists as a homodimer on the surface of monocytes, neutrophils, granulocytes, peripheral T cells, some B cells, and a subset of CD34+ hematopoietic progenitor cells (HPCs) in the bone marrow. CD162 binds CD62P (P-selectin), CD62E (E-selectin), and CD62L (L-selectin) to mediate leukocyte interactions with each other as well as with activated platelets and endothelium. Thus, CD162 plays a critical role in leukocyte adhesion and rolling. Furthermore, the binding of CD162 to P-selectin on HPCs has been demonstrated to inhibit hematopoiesis. Studies have also demonstrated CD162 as the receptor for enterovirus 71.