CD160 Rat anti-Mouse, Clone: eBioCNX46-3 (CNX46-3), eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-1601-85

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15217267

Quantity Price
1 £ 158.36 / 500µg
Estimated Shipment date
from Supplier 04-04-2017
Add to basket


Description and Specification

Specification

Gene Alias BY55
Regulatory Status RUO
Monoclonal or Polyclonal Monoclonal
Antigen CD160
Isotype IgG2a
Primary or Secondary Primary
Applications Flow Cytometry
Applications Functional Assay
Applications Immunoprecipitation
Applications Western Blotting
Format Purified
Storage Requirements Store at 2-8°C.
Species Reactivity Mouse
Concentration 0.5mg/mL
Conjugate Unlabeled
Host Species Rat
Clone eBioCNX46-3 (CNX46-3)
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Quantity 500μg

CD160 is a glycosylphosphatidylinositol (GPI)-anchored Ig-like glycoprotein first identified on human lymphocytes with the monoclonal antibody BY55. In mice, CD160 is expressed on almost all (intestinal intraepithelial lymphocytes) iIELs, NKT cells, most TCRγδ T cells, few NK cells and a minor subset of CD8+ T cells. Murine CD160 has been shown to bind to a wide range of classical and non classical MHC class I molecules and regulate NK cell activation. In vitro, CD3 activation of murine CD8+ T cells increases the expression of CD160 and induces the release of soluble CD160 (sCD160). In human, CD160 mAb cross-linking triggers TNF alpha, IFN gamma and IL-6 cytokine production by peripheral blood NK cells and inhibits tube formation and induces apoptosis of endothelial cells. In mice, cross-linking of CD160 with the CNX46-3 antibody regulates NK cell activation both positively and negatively, depending on the stimulus.