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CD160 Monoclonal Antibody (eBioCNX46-3 (CNX46-3)), eBioscience™, Invitrogen™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-1601-81

42.83 GBP valid until 2024-03-29
Use promo code "21615" to get your promotional price.



Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15207267

  • £64.25 / 50µg
Estimated Shipment: 08-05-2024
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Description

Description

Description: CD160 is a glycosylphosphatidylinositol (GPI)-anchored Ig-like glycoprotein first identified on human lymphocytes with the monoclonal antibody BY55. In mice, CD160 is expressed on almost all (intestinal intraepithelial lymphocytes) iIELs, NKT cells, most TCRgammadelta T cells, few NK cells and a minor subset of CD8+ T cells. Murine CD160 has been shown to bind to a wide range of classical and non classical MHC class I molecules and regulate NK cell activation. In vitro, CD3 activation of murine CD8+ T cells increases the expression of CD160 and induces the release of soluble CD160 (sCD160). In human, CD160 mAb cross-linking triggers TNF alpha, IFN gamma and IL-6 cytokine production by peripheral blood NK cells and inhibits tube formation and induces apoptosis of endothelial cells. In mice, cross-linking of CD160 with the CNX46-3 antibody regulates NK cell activation both positively and negatively, depending on the stimulus. Applications Reported: This eBioCNX46-3 (CNX46-3) antibody has been reported for use in flow cytometric analysis, immunoprecipitation, and immunoblotting (WB). (Please use Functional Grade purified eBioCNX46-3 (CNX46-3), cat. 16-1601, in functional assays.). Applications Tested: This eBioCNX46-3 (CNX46-3) antibody has been tested by flow cytometric analysis of C57Bl/6 mouse splenocytes. This can be used at less than or equal to 1 μg per test.

CD160 is a receptor showing broad specificity for both classical and non-classical MHC class I molecules. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. It is involved in cell proliferation, cell surface receptor signaling pathways, cellular defense response, and regulation of immune response.
Specifications

Specifications

CD160
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
O88875
CD160
Affinity chromatography
RUO
54215
4° C
Liquid
Flow Cytometry, Functional Assay, Immunoprecipitation, Western Blot
eBioCNX46-3 (CNX46-3)
Unconjugated
CD160
AU045688; BY55; CD160; CD160 antigen; CD160 antigen, soluble form; CD160 molecule; CD160 transmembrane isoform; CD160-delta Ig; natural killer cell BY55; natural killer cell receptor; natural killer cell receptor BY55; natural killer cell receptor, immunoglobulin superfamily member; NK1; NK28; RGD1563598
Rat
50 μg
Primary
Mouse
Antibody
IgG2a κ
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