CD16 Mouse anti-Human, PE-Cy5, Clone: eBioCB16 (CB16), eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 15-0168-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15567716

Quantity Price
1 £ 72.77 / 25 tests
Estimated Shipment date
from Supplier 04-05-2017
Add to basket


Description and Specification

Specification

Applications Flow Cytometry
Regulatory Status RUO
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Host Species Mouse
Monoclonal or Polyclonal Monoclonal
Clone eBioCB16 (CB16)
Primary or Secondary Primary
Conjugate PE-Cy5
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 5μL (0.25μg)/test
Quantity 25 tests
Antigen CD16
Species Reactivity Human
Gene Alias Low Affinity IgG Receptor 3, FCGR3, IGFR4
Isotype IgG1
Format Conjugated

The eBioCB16 monoclonal antibody recognizes CD16 (Fc gammaRIII), the low-affinity receptor for IgG with an apparent molecular weight of 50-80 kDa. CD16 is represented by two similar genes, CD16A (Fc gammaRIIIA), which exists as a hetero-oligomeric polypeptide-anchored form in macrophages and NK cells and CD16B (Fc gammaRIIIB), which exist as a monomeric GPI-anchored form in neutrophils. Furthermore, there are two known polymorphisms of CD16B, NA-1 and NA-2. Individuals homozygous for NA-2 show a lower phagocytic capacity compared with NA-1. CD16 binds IgG in the form of immune complexes and shows preferential binding of IgG1 and IgG3 isotypes and minimal binding of IgG2 and IgG4. Upon IgG binding, both CD16 isoforms initiate signal transduction cascades that lead to a variety of responses including antibody-dependent cell-mediated cytotoxicity (ADCC), phagocytosis, degranulation and proliferation.