missing translation for 'onlineSavingsMsg'
Learn More

CD16 Mouse anti-Human, Non-human primate, Clone: 3G8, Functional Grade, eBioscience™

Mouse Monoclonal Antibody, Functional Grade

Brand:  Affymetrix eBioscience 16-0166-85

Code : NEW

Additional Details : Weight : 0.09500kg

 View more versions of this product

Product Code. 15527776

  • £237.85 / 500µg


Estimated Shipment date
from Supplier 25-09-2017
Add to basket

Disclaimers:

For Research Use Only.


Description

Description

This 3G8 monoclonal antibody reacts with human and non-human primate CD16, which is also known as the low-affinity Fc gamma RIII. CD16 exists as two distinct isoforms, Fc gamma RIIIA and Fc gamma RIIIB. In humans, Fc gamma RIIIA is expressed as a polypeptide-anchored form on monocytes, macrophages, and lymphocytes such as NK cells. T and B cells do not express this Fc receptor. Fc gamma RIIIB is also detected on neutrophils as a GPI-anchored form. Expression of CD16 on lymphocytes and monocytes is similar in non-human primates. However, while CD16 is not found on neutrophils in macaques and baboons, this receptor is detected on these cells in sooty mangabeys. Binding of IgG leads to activation of signal transduction pathways, resulting in antibody-dependent cell-mediated cytotoxicity (ADCC), phagocytosis, cytokine release, and antigen presentation.

This monoclonal antibody has been reported to have several functional activities, including inhibition of cytotoxic ability, activation of cell signaling, and NK cell depletion in vivo. Moreover, the 3G8 antibody clone has been demonstrated to work on capuchin monkey, chimpanzee, common marmoset, cynomologous monkey, hamadyras baboon, olive baboon, pigtailed macaque, rhesus, and squirrel monkey.

Based on cross-blocking studies 3G8 recognizes the same epitope as CB16. However, 3G8 and B73.1 antibody clones bind distinct epitopes.
Specifications

Specifications

CD16
3G8
Unlabeled
Purified
Murine
500μg
Store at 2-8°C.
Monoclonal
Functional Assay
1mg/mL
aqueous buffer, no sodium azide
FcgRIII, FcgR3, ADCC receptor
IgG1
RUO
Primary
Rhesus