CD16 Mouse anti-Human, Biotin, Clone: eBioCB16 (CB16), eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 13-0168-80

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15269469

Quantity Price
1 £ 54.42 / 25µg
Estimated Shipment date
from Supplier 10-05-2017
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Description and Specification

Specification

Storage Requirements Store at 2-8°C. Do not freeze.
Antigen CD16
Conjugate Biotin
Concentration 0.5mg/mL
Isotype IgG1
Quantity 25μg
Primary or Secondary Primary
Clone eBioCB16 (CB16)
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Species Reactivity Human
Format Conjugated
Regulatory Status RUO
Monoclonal or Polyclonal Monoclonal
Host Species Mouse
Applications Flow Cytometry
Gene Alias Low Affinity IgG Receptor 3, FCGR3a, FCGR3, IGFR6

The eBioCB16 monoclonal antibody recognizes CD16 (Fc gammaRIII), the low-affinity receptor for IgG with an apparent molecular weight of 50-80 kDa. CD16 is represented by two similar genes, CD16A (Fc gammaRIIIA), which exists as a hetero-oligomeric polypeptide-anchored form in macrophages and NK cells and CD16B (Fc gammaRIIIB), which exist as a monomeric GPI-anchored form in neutrophils. Furthermore, there are two known polymorphisms of CD16B, NA-1 and NA-2. Individuals homozygous for NA-2 show a lower phagocytic capacity compared with NA-1. CD16 binds IgG in the form of immune complexes and shows preferential binding of IgG1 and IgG3 isotypes and minimal binding of IgG2 and IgG4. Upon IgG binding, both CD16 isoforms initiate signal transduction cascades that lead to a variety of responses including antibody-dependent cell-mediated cytotoxicity (ADCC), phagocytosis, degranulation and proliferation.