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CD158a/h/g Mouse anti-Human, PE, Clone: HP-MA4, eBioscience™

Mouse Monoclonal Antibody

£65.75 - £166.00

Specifications

Antigen CD158a/h/g
Clone HP-MA4
Target Species Human
Conjugate PE
Isotype IgG2b, kappa
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15596906
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Affymetrix eBioscience
12-1589-41
25 Tests
£65.75
25 tests
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Estimated Shipment
02-12-2020
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15506916
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Affymetrix eBioscience
12-1589-42
100 Tests
£166.00
100 tests
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Save Up to 
»
Estimated Shipment
02-12-2020
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Description

Description

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several ""framework"" genes are found in all haplotypes. The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.
Specifications

Specifications

CD158a/h/g
Human
IgG2b, kappa
Monoclonal
Liquid
Antibody
4° C, store in dark, DO NOT FREEZE!
HP-MA4
PE
Flow Cytometry
Primary
Monoclonal
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
RUO
SDS

For Research Use Only.