CD157 Mouse anti-Human, PE, Clone: eBioSY11B5 (SY11B5), eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-1579-42

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15566906

Quantity Price
1 £ 174.09 / 100 tests
EU Stock 16
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Description and Specification

Specification

Quantity 100 Tests
Host Species Murine
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Species Reactivity Human
Isotype IgG1
Conjugate PE
Clone eBioSY11B5 (SY11B5)
Primary or Secondary Primary
Gene Alias BST-1, BP-3/IF-7
Regulatory Status RUO
Concentration 5μL (0.125μg)/test
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Format Conjugated
Monoclonal or Polyclonal Monoclonal
Applications Flow Cytometry
Antigen CD157

The eBioSY11B5 monoclonal antibody recognizes human CD157 (Mo5, BST-1). CD157 is a 42-45 kDa, GPI-anchored protein with structural and functional similarities with CD38. CD157 was initially cloned because of its expression on monocytes and macrophages, and was subsequently discovered to be the same protein named BST-1, discovered for its expression on bone marrow stromal cells and its ability to stimulate the proliferation of a mouse pre-B cell line. CD157 is a pleiotropic ectoenzyme and is thought to act independently as an enzyme and receptor. Similar to CD38, CD157 is involved in the metabolism of NAD+ and this activity may be involved in regulating intracellular Ca2+ levels. As a receptor, upon binding of its putative ligand, CD157 is thought to initiate a signal transduction cascade resulting in the phosphorylation of cytoplasmic proteins including focal adhesion kinase (FAK). The mechanism and functional significance of CD157-initiated signal transduction remain to be fully characterized.