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CD157, clone: eBioSY11B5 (SY11B5), eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-1579-82

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15297257

  • £62.12 / 100µg


EU Stock 1
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Description

Description

Description: The eBioSY11B5 monoclonal antibody recognizes human CD157 (Mo5, BST-1). CD157 is a 42-45 kDa, GPI-anchored protein with structural and functional similarities with CD38. CD157 was initially cloned because of its expression on monocytes and macrophages, and was subsequently discovered to be the same protein named BST-1, discovered for its expression on bone marrow stromal cells and its ability to stimulate the proliferation of a mouse pre-B cell line. CD157 is a pleiotropic ectoenzyme and is thought to act independently as an enzyme and receptor. Similar to CD38, CD157 is involved in the metabolism of NAD+ and this activity may be involved in regulating intracellular Ca2+ levels. As a receptor, upon binding of its putative ligand, CD157 is thought to initiate a signal transduction cascade resulting in the phosphorylation of cytoplasmic proteins including focal adhesion kinase (FAK). The mechanism and functional significance of CD157-initiated signal transduction remain to be fully characterized.Applications Reported: This eBioSY11B5 (SY11B5) antibody has been reported for use in flow cytometric analysis, immunoprecipitation, immunoblotting (WB) (non-reduced only), and immunohistology staining of frozen tissue sections.Applications Tested: This eBioSY11B5 (SY11B5) antibody has been tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at less than or equal to 0.5 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Purity: Greater than 90%, as determined by SDS-PAGE.Aggregation: Less than 10%, as determined by HPLC.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

CD157
Monoclonal
0.5mg/mL
PBS with 0.09% sodium azide; pH 7.2
Q10588
Bone marrow stromal cell antigen 1, ADP-ribosyl cyclase 2, BST-1, NAD+ nucleosidase, bone marrow stromal antigen 1, cADPr hydrolase 2, cyclic ADP-ribose hydrolase 2
Murine
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow CytometryþImmunohistochemistry (Frozen)þImmunoprecipitationþWestern Blot
eBioSY11B5 (SY11B5)
Unconjugated
BST1
Purified
BST1
IgG1, kappa
100μg
Store at 2-8°C.
Primary
683
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