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CD154 (CD40 Ligand) Monoclonal Antibody (24-31), eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

£72.25 - £166.00

Specifications

Antigen CD154 (CD40 Ligand)
Clone 24-31
Concentration 0.5 mg/mL
Applications Flow Cytometry, Functional Assay, Neutralization
Classification Monoclonal
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Products 2
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Product Code Brand Quantity Price Quantity & Availability  
15277257
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Affymetrix eBioscience
14-1548-82
100 μg
£166.00
100µg
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15267257
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Affymetrix eBioscience
14-1548-80
25 μg This item is currently unavailable or has been discontinued.
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Description

Description

Description: The 24-31 monoclonal antibody reacts with human CD154, a 39 kDa transmembrane glycoprotein also known as gp39 and CD40 ligand (CD40L). CD154 is a member of the TNF superfamily and is expressed transiently by activated T cells. Through its binding to CD40 on antigen presenting cells including B cells, monocytes/macrophages and dendritic cells, CD154 serves a crucial function in T-APC cognate interaction. CD154 interaction with CD40 transduces signals for T-dependent B-cell activation and induces B cell cycle entry. 24-31 cross-reacts with the cynomolgus monkey CD154. Applications Reported: 24-31 has been reported for use in flow cytometric analysis. 24-31 has also been reported to block CD154 binding to CD40 and inhibit T cell-dependent B cell differentiation and antibody response in vitro . (Please use Functional Grade Purified 24-31, cat. 16-1548, in functional assays.). Applications Tested: The 24-31 antibody has been tested by flow cytometric analysis of resting and activated human normal human peripheral blood cells. This can be used at less than or equal to 1 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

CD40 Ligand (CD40-L), or CD154, is a membrane glycoprotein and differentiation antigen expressed on the surface of T cells. The CD40 Ligand stimulates B cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. CD40 Ligand has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. It also co-stimulates proliferation of activated T cells and this is accompanied by the production of IFN-gamma, TNF-alpha, and IL-2.
Specifications

Specifications

CD154 (CD40 Ligand)
0.5 mg/mL
Monoclonal
Liquid
RUO
P29965
CD40LG
Primary
4° C
CD40LG
24-31
Flow Cytometry, Functional Assay, Neutralization
Unconjugated
Mouse
Cynomolgus Monkey, Human
102138630, 959
IgG1 κ
Affinity chromatography
Antibody
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