CD152 (CTLA-4) Mouse anti-Human, PE, Clone: 20A, A3, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-1528-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15596896

Quantity Price
1 £ 60.53 / 25 tests
Estimated Shipment date
from Supplier 08-05-2017
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Description and Specification

Specification

Quantity 25 Tests
Host Species Murine
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Conjugate PE
Isotype IgG2a
Clone A3)
Regulatory Status RUO
Gene Alias CTLA4
Monoclonal or Polyclonal Monoclonal
Applications Flow Cytometry
Species Reactivity Human
Format Conjugated
Primary or Secondary Primary
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Concentration 5μL (0.125μg)/test
Antigen CD152 (CTLA-4)

The eBio20A monoclonal antibody reacts with human CD152, also known as cytotoxic T lymphocyte antigen-4 (CTLA-4). CTLA-4, a protein with structural similarities to CD28, is expressed on activated T cells (activated B cells may also express CTLA-4) and binds the B7 family members, CD80 (B7-1) and CD86 (B7-2), with higher affinity than CD28 does. CTLA-4 and CD28 appear to deliver opposing signals to T cells: while CD28 is a potent costimulator, CTLA-4 restricts the progression of T cells to an activated state by inhibiting IL-2 secretion and cellular proliferation. The cytoplasmic portion of CTLA-4 contains ER retention motifs, resulting in intracellular localization of a large proportion of newly synthesized CTLA-4 in response to TCR signaling.