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CD152 (CTLA-4) Mouse anti-Human, Clone: 14D3, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-1529-80

UNSPSC : 12352200

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15297247

  • £48.31 / 25µg


Estimated Shipment
03-08-2017
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Disclaimers:

For Research Use Only.


Specifications

Description

The 14D3 monoclonal antibody reacts with human CD152, also known as cytotoxic T lymphocyte antigen-4 (CTLA-4). CTLA-4, a protein with structural similarities to CD28, is expressed on activated T cells (activated B cells may also express CTLA-4) and binds the B7 family members, CD80 (B7-1) and CD86 (B7-2), with higher affinity than CD28 does. CTLA-4 and CD28 appear to deliver opposing signals to T cells: while CD28 is a potent costimulator, CTLA-4 restricts the progression of T cells to an activated state by inhibiting IL-2 secretion and cellular proliferation. The cytoplasmic portion of CTLA-4 contains ER retention motifs, resulting in intracellular localization of a large proportion of newly synthesized CTLA-4 in response to TCR signaling.

The 14D3 antibody also recognizes rhesus monkey and has inhibitor activity.
Description & Specifications

Specifications

CD152 (CTLA-4)
14D3
Unlabeled
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
IgG2a
RUO
Primary
Rhesus
Functional Assay
0.5mg/mL
Purified
Murine
25μg
Store at 2-8°C.
Monoclonal