missing translation for 'onlineSavingsMsg'
Learn More

CD152 (CTLA-4) Golden Syrian Hamster anti-Mouse, Clone: 9H10, Functional Grade, eBioscience™

Golden Syrian Hamster Monoclonal Antibody, Functional Grade

Brand:  Affymetrix eBioscience 16-1521-81

Code : Z2

Additional Details : Weight : 0.01000kg

 View more versions of this product

Product Code. 15278567

  • £54.42 / 50µg


Call for latest availability
+44 (0)1509 555 500
Add to basket

Disclaimers:

For Research Use Only.


Description

Description

The 9H10 monoclonal antibody reacts with mouse CD152, also known as the cytotoxic T lymphocyte antigen-4 (CTLA-4). CTLA-4, a protein with structural similarities to CD28, is expressed on activated T cells and binds the B7 family members, CD80 (B7-1) and CD86 (B7-2), with higher affinity than CD28 does. CTLA-4 and CD28 appear to deliver opposing signals to T cells: while CD28 is a potent costimulator, CTLA-4 restricts the progression of T cells to an activated state by inhibiting IL-2 secretion and cellular proliferation. The cytoplasmic portion of CTLA-4 contains ER retention motifs, resulting in a large proportion of newly synthesized CTLA-4 in response to TCR signaling to be localized intracellularly.
Specifications

Specifications

CD152 (CTLA-4)
9H10
Unconjugated
Purified
Golden Syrian Hamster
50μg
Store at 2-8°C.
Monoclonal
Functional Assay
1mg/mL
aqueous buffer, no sodium azide
CTLA4
IgG
RUO
Primary
Murine
Videos