CD152 (CTLA-4) Golden Syrian Hamster anti-Mouse, Clone: 9H10, Functional Grade, eBioscience™

Golden Syrian Hamster Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-1521-81

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15278567

Quantity Price
1 £ 54.42 / 50µg
Estimated Shipment date
from Supplier 01-06-2017
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Description and Specification

Specification

Antigen CD152 (CTLA-4)
Applications Flow Cytometry
Applications Functional Assay
Clone 9H10
Concentration 1mg/mL
Conjugate Unlabeled
Format Purified
Formulation aqueous buffer, no sodium azide
Gene Alias CTLA4
Host Species Golden Syrian Hamster
Isotype IgG
Quantity 50μg
Regulatory Status RUO
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Target Species Murine

The 9H10 monoclonal antibody reacts with mouse CD152, also known as the cytotoxic T lymphocyte antigen-4 (CTLA-4). CTLA-4, a protein with structural similarities to CD28, is expressed on activated T cells and binds the B7 family members, CD80 (B7-1) and CD86 (B7-2), with higher affinity than CD28 does. CTLA-4 and CD28 appear to deliver opposing signals to T cells: while CD28 is a potent costimulator, CTLA-4 restricts the progression of T cells to an activated state by inhibiting IL-2 secretion and cellular proliferation. The cytoplasmic portion of CTLA-4 contains ER retention motifs, resulting in a large proportion of newly synthesized CTLA-4 in response to TCR signaling to be localized intracellularly.