CD152 (CTLA-4) Armenian Hamster anti-Mouse, Biotin, Clone: UC10-4B9, eBioscience™

Armenian Hamster Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 13-1522-85

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15279739

Quantity Price
1 £ 158.36 / 500µg
EU Stock 2
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Description and Specification

Specification

Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Conjugate Biotin
Antigen CD152 (CTLA-4)
Quantity 500μg
Species Reactivity Mouse
Clone UC10-4B9
Host Species Armenian Hamster
Storage Requirements Store at 2-8°C. Do not freeze.
Regulatory Status RUO
Isotype IgG
Concentration 0.5mg/mL
Format Conjugated
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Applications Flow Cytometry

The UC10-4B9 monoclonal antibody reacts with mouse CD152, also known as the cytotoxic T lymphocyte antigen-4 (CTLA-4). CTLA-4, a protein with structural similarities to CD28, is expressed on activated T cells at low level and binds the B7 family members, CD80 (B7-1) and CD86 (B7-2), with higher affinity than CD28 does. CTLA-4 and CD28 appear to deliver opposing signals to T cells: while CD28 is a potent costimulator, CTLA-4 restricts the progression of T cells to an activated state by inhibiting IL-2 secretion and cellular proliferation. The cytoplasmic portion of CTLA-4 contains ER retention motifs, resulting in a large proportion of newly synthesized CTLA-4 in response to TCR signaling to be localized intracellularly.
Furthermore, due to the intracellular localization of a large portion of CTLA-4, for complete detection it may be necessary to assess intracellular expression, in addition to surface expression of CTLA-4.