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CD151 Mouse anti-Human, APC, Clone: 50-6, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 17-1519-42

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15578016

  • £176.70 / 100 tests


Estimated Shipment date
from Supplier 30-10-2017
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Disclaimers:

For Research Use Only.


Description

Description

The monoclonal antibody 50-6 recognizes human CD151 also known as PETA-3 (platelet-endothelial cell tetraspan antigen-3). CD151 has a molecular weight of 29kDa and like other tetraspanin family members, CD151 contains four hydrophobic transmembrane domains, two short cytoplasmic tails, and one small and one large extracellular loop. CD151 is expressed on platelets, megakaryocytes, endothelial cells, at the cell-cell junctions, as well as epithelial cells where it localizes to basolateral surfaces exposed to extracellular matrix. The tetraspanins play a role in cell adhesion and migration; CD151 interacts with integrinα3 β1 and integrinα6 β4. In particular CD151 forms a functional complex with c-Met and integrin α3 and α6 in human salivary gland cancer cells. Additionally it can interact with CD46. Together these interactions are thought to play a role during early metastasis as a potential positive effector.
The 50-6 monoclonal antibody inhibits in vivo metastasis of a human epidermal carcinoma cell line, HEp-3.
Specifications

Specifications

CD151
50-6
Allophycocyanin
Conjugated
Murine
100 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry
5μL (0.125μg)/test
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
PETA-3, PETA3
IgG1
RUO
Primary
Human