CD151 Mouse anti-Human, APC, Clone: 50-6, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 17-1519-41

25TEST Anti-Human CD151 APC

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15568016

Quantity Price
1 £ 129.5 / 25 tests
Estimated Shipment date
from Supplier 08-12-2016
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Description and Specification

Specification

Antigen CD151
Applications Flow Cytometry
Clone 50-6
Concentration 5μL (0.125μg)/test
Conjugate APC
Format Conjugated
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Gene Alias PETA-3, PETA3
Host Species Mouse
Isotype IgG1
Quantity 25 tests
Regulatory Status RUO
Species Reactivity Human
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal

The monoclonal antibody 50-6 recognizes human CD151 also known as PETA-3 (platelet-endothelial cell tetraspan antigen-3). CD151 has a molecular weight of 29kDa and like other tetraspanin family members, CD151 contains four hydrophobic transmembrane domains, two short cytoplasmic tails, and one small and one large extracellular loop. CD151 is expressed on platelets, megakaryocytes, endothelial cells, at the cell-cell junctions, as well as epithelial cells where it localizes to basolateral surfaces exposed to extracellular matrix. The tetraspanins play a role in cell adhesion and migration; CD151 interacts with integrinα3 β1 and integrinα6 β4. In particular CD151 forms a functional complex with c-Met and integrin α3 and α6 in human salivary gland cancer cells. Additionally it can interact with CD46. Together these interactions are thought to play a role during early metastasis as a potential positive effector.
The 50-6 monoclonal antibody inhibits in vivo metastasis of a human epidermal carcinoma cell line, HEp-3.