CD146 Mouse, eFluor 450, Clone: P1H12, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 48-1469-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15599716

Quantity Price
1 £ 67.87 / 25 tests
Estimated Shipment date
from Supplier 03-04-2017
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Description and Specification

Specification

Species Reactivity Canine, Human, Mouse, Rabbit
Isotype IgG1
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Gene Alias Melanoma Cell Adhesion Molecule, MUC18, Mel-CAM, EndoCAM
Host Species Mouse
Monoclonal or Polyclonal Monoclonal
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Conjugate eFluor 450
Antigen CD146
Primary or Secondary Primary
Concentration 5μL (0.125μg)/test
Format Conjugated
Quantity 25 tests
Regulatory Status RUO
Applications Flow Cytometry
Clone P1H12

The monoclonal antibody P1H12 recognizes CD146 also known as MUC18, s-endo, Endo-CAM and Mel-CAM, which is a member of the Ig superfamily of proteins. The expression of CD146 is found on endothelial cells, bone marrow fibroblasts and some tumors (especially melanoma). Recently mesenchymal stromal cells and endometrial stromal cells have also been shown to express CD146. The presence of CD146 on circulating blood cells have been confined to a subset of T cells rather than circulating endothelial cells, as expression of other endothelial markers (CD31 and CD51/61) is negative. Expression can be found on activated lymphocytes. The protein is heavily glycosylated with more than 50% of the mass from carbohydrates.

The antibody P1H12 has been reported to crossreact to mouse, rabbit, canine, but not rat.