CD144 (VE-Cadherin) Rat anti-Mouse, Clone: eBioBV13 (BV13), Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-1441-85

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15218567

Quantity Price
1 £ 213.39 / 500µg
Estimated Shipment date
from Supplier 08-05-2017
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Description and Specification

Specification

Applications Flow Cytometry
Applications Functional Assay
Applications Immunohistochemistry (Frozen)
Applications Immunoprecipitation
Applications Western Blot
Format Purified
Concentration 1mg/mL
Gene Alias Cdh5, Cadherin-5, Vascular endothelial cadherin
Storage Requirements Store at 2-8°C.
Monoclonal or Polyclonal Monoclonal
Clone eBioBV13 (BV13)
Antigen CD144 (VE-Cadherin)
Regulatory Status RUO
Primary or Secondary Primary
Isotype IgG1
Quantity 500μg
Formulation aqueous buffer, no sodium azide
Conjugate Unlabeled
Species Reactivity Mouse
Host Species Rat

The BV13 monoclonal antibody reacts with mouse VE-Cadherin (CD144). VE-Cadherin is a 120kDa member of the type II Cadherin family, characterized by the presence of 5 extracellular cadherin domains (ECD), and anchored to the actin cytoskeleton through their cytoplasmic tail. VE-Cadherin mediates homophilic adhesion between neighbouring endothelial cells and is localized within specialized structures at cell-cell contacts, called adherens junctions. VE-Cadherin is expressed constitutively throughout the entire vasculature, and is required for numerous endothelial cell functions including migration, survival, contact-dependent growth inhibition and endothelial cell assembly into tubular structures. Furthermore, it is thought that VE-Cadherin+CD45- cells from the yolk sac or aorta-gonad-mesonephros (AGM) have the potential to give rise to hematopoietic cells.