CD144 (VE-Cadherin) Rat anti-Mouse, Clone: eBioBV13 (BV13), Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-1441-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15208567

Quantity Price
1 £ 115.56 / 100µg
Estimated Shipment date
from Supplier 02-05-2017
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Description and Specification

Specification

Species Reactivity Mouse
Gene Alias Cdh5, Cadherin-5, Vascular endothelial cadherin
Primary or Secondary Primary
Applications Flow Cytometry
Applications Functional Assay
Applications Immunohistochemistry (Frozen)
Applications Immunoprecipitation
Applications Western Blotting
Clone eBioBV13 (BV13)
Isotype IgG1
Concentration 1mg/mL
Format Purified
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, no sodium azide
Host Species Rat
Regulatory Status RUO
Antigen CD144 (VE-Cadherin)
Conjugate Unlabeled
Storage Requirements Store at 2-8°C.
Quantity 100μg

The BV13 monoclonal antibody reacts with mouse VE-Cadherin (CD144). VE-Cadherin is a 120kDa member of the type II Cadherin family, characterized by the presence of 5 extracellular cadherin domains (ECD), and anchored to the actin cytoskeleton through their cytoplasmic tail. VE-Cadherin mediates homophilic adhesion between neighbouring endothelial cells and is localized within specialized structures at cell-cell contacts, called adherens junctions. VE-Cadherin is expressed constitutively throughout the entire vasculature, and is required for numerous endothelial cell functions including migration, survival, contact-dependent growth inhibition and endothelial cell assembly into tubular structures. Furthermore, it is thought that VE-Cadherin+CD45- cells from the yolk sac or aorta-gonad-mesonephros (AGM) have the potential to give rise to hematopoietic cells.