CD144 (VE-Cadherin) Rat anti-Mouse, Clone: eBioBV13 (BV13), eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-1441-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15277227

Quantity Price
1 £ 97.22 / 100µg
EU Stock 1
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Description and Specification

Specification

Applications Flow Cytometry
Applications Functional Assay
Applications Immunohistochemistry (Frozen)
Applications Immunoprecipitation
Applications Western Blotting
Conjugate Unlabeled
Primary or Secondary Primary
Format Purified
Species Reactivity Mouse
Gene Alias Cdh5, Cadherin-5, Vascular endothelial cadherin
Monoclonal or Polyclonal Monoclonal
Isotype IgG1
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Storage Requirements Store at 2-8°C.
Concentration 0.5mg/mL
Quantity 100μg
Antigen CD144 (VE-Cadherin)
Regulatory Status RUO
Host Species Rat
Clone eBioBV13 (BV13)

The BV13 monoclonal antibody reacts with mouse VE-Cadherin (CD144). VE-Cadherin is a 120kDa member of the type II Cadherin family, characterized by the presence of 5 extracellular cadherin domains (ECD), and anchored to the actin cytoskeleton through their cytoplasmic tail. VE-Cadherin mediates homophilic adhesion between neighbouring endothelial cells and is localized within specialized structures at cell-cell contacts, called adherens junctions. VE-Cadherin is expressed constitutively throughout the entire vasculature, and is required for numerous endothelial cell functions including migration, survival, contact-dependent growth inhibition and endothelial cell assembly into tubular structures. Furthermore, it is thought that VE-Cadherin+CD45- cells from the yolk sac or aorta-gonad-mesonephros (AGM) have the potential to give rise to hematopoietic cells.