CD141 Rat anti-Mouse, PE, Clone: LS17-9, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-1411-80

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15596886

Quantity Price
1 £ 78.88 / 25µg
Estimated Shipment date
from Supplier 04-05-2017
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Description and Specification

Specification

Concentration 0.2mg/mL
Format Conjugated
Gene Alias Thrombomodulin, BDCA-3
Quantity 25μg
Regulatory Status RUO
Monoclonal or Polyclonal Monoclonal
Isotype IgG2a
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Host Species Rat
Primary or Secondary Primary
Clone LS17-9
Conjugate PE
Applications Flow Cytometry
Species Reactivity Mouse
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Antigen CD141

The monoclonal antibody LS17-9 recognizes mouse CD141 (Thrombomodulin, BDCA-3), a type I cell surface glycoprotein that binds to and allosterically activates thrombin. This complex cleaves protein C and the Thrombin Activatable Fibrinolysis Inhibitor (TAFI), initiating an important anticoagulant and antifibrinolytic pathway. Although expressed across many tissues and cell types, its highest expression has been reported on the lumenal surface of vascular endothelial cell. In the immune system the highest expression can be observed on monocytes and macrophages. Soluble CD141 is constitutively present in the serum at a very low level, and can be upregulated during inflammation. The anti-inflammatory activity of CD141 results from its ability to block the highly pro-inflammatory activity of thrombin. CD141 prevents chemotaxis and binding of granulocytes to activated endothelium, and inhibits activation of eosinophils and mast cells thereby reducing inflammation. Although human CD141 is commonly used as a marker of cross-presenting dendritic cells, mouse CD141 does not exhibit the same expression pattern.