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CD141 Rat anti-Mouse, Alexa Fluor 488, Clone: LS17-9, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 53-1411-80

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15550197

  • £78.88 / 25µg


Estimated Shipment date
from Supplier 24-08-2017
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Disclaimers:

For Research Use Only.


Specifications

Description

The monoclonal antibody LS17-9 recognizes mouse CD141 (Thrombomodulin, BDCA-3), a type I cell surface glycoprotein that binds to and allosterically activates thrombin. This complex cleaves protein C and the Thrombin Activatable Fibrinolysis Inhibitor (TAFI), initiating an important anticoagulant and antifibrinolytic pathway. Although expressed across many tissues and cell types, its highest expression has been reported on the lumenal surface of vascular endothelial cell. In the immune system the highest expression can be observed on monocytes and macrophages. Soluble CD141 is constitutively present in the serum at a very low level, and can be upregulated during inflammation. The anti-inflammatory activity of CD141 results from its ability to block the highly pro-inflammatory activity of thrombin. CD141 prevents chemotaxis and binding of granulocytes to activated endothelium, and inhibits activation of eosinophils and mast cells thereby reducing inflammation. Although human CD141 is commonly used as a marker of cross-presenting dendritic cells, mouse CD141 does not exhibit the same expression pattern.
Description & Specifications

Specifications

CD141
LS17-9
Alexa Fluor 488
Conjugated
Rat
25μg
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Immunohistochemistry (Frozen)
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Thrombomodulin, BDCA-3
IgG2a
RUO
Primary
Murine