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CD140b (PDGFRB) Monoclonal Antibody (APB5), Biotin, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

£41.67 - £151.00

Specifications

Antigen CD140b (PDGFRB)
Clone APB5
Concentration 0.5 mg/mL
Applications Flow Cytometry
Classification Monoclonal
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15269729
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Affymetrix eBioscience
13-1402-82
100 μg
£151.00
100µg
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15259729
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Affymetrix eBioscience
13-1402-80
25 μg This item is currently unavailable or has been discontinued.
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Description

Description

Description: The APB5 monoclonal antibody reacts with the mouse CD140b molecule, the beta chain of the platelet derived growth factor receptor (PDGF receptor). PDGFRb is a receptor tyrosine kinase that forms dimers on the surface upon ligand binding and phosphorylates substrates. Dimers of PDGFR consist of either homodimers of alpha/alpha, beta/beta, or heterodimers of alpha/beta and serve as a substrate for its kinase activity. CD140b is expressed by embryonic tissues and mesenchymal-derived cells of the adult mouse tissues. The PDGFR beta chain is reported to play a significant role in formation of fibrous atherosclerotic lesions. Applications Reported: The APB5 antibody has been reported for use in flow cytometric analysis. Applications Tested: The APB5 antibody has been tested by flow cytometric analysis of NIH/3T3 cells. This can be used at less than or equal to 1 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Filtration: 0.2 μm post-manufacturing filtered.

PDGFRB is a receptor tyrosine kinase and has been implicated in atherogenesis and in cell transformation by the SIS oncogene. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. The gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses PDGFRB (CD140b) to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.
Specifications

Specifications

CD140b (PDGFRB)
0.5 mg/mL
Monoclonal
Liquid
RUO
P05622
Pdgfrb
Primary
4° C, store in dark, DO NOT FREEZE!
Pdgfrb
APB5
Flow Cytometry
Biotin
Rat
Mouse
18596
IgG2a κ
Affinity chromatography
Antibody
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