CD137 (4-1BB) Golden Syrian Hamster anti-Mouse, PE, Clone: 17B5, eBioscience™

Golden Syrian Hamster Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-1371-83

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15298669

Quantity Price
1 £ 180.2 / 200µg
Estimated Shipment date
from Supplier 03-04-2017
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Description and Specification

Specification

Concentration 0.2mg/mL
Gene Alias Ly-63, TNFRSF9, ILA
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Antigen CD137 (4-1BB)
Format Conjugated
Host Species Golden Syrian Hamster
Quantity 200μg
Primary or Secondary Primary
Clone 17B5
Regulatory Status RUO
Species Reactivity Mouse
Applications Flow Cytometry
Monoclonal or Polyclonal Monoclonal
Isotype IgG
Conjugate PE

The 17B5 monoclonal antibody reacts with mouse CD137, also known as 4-1BB, a member of the TNFR superfamily. CD137 is expressed as monomers, dimers, and tetramers on the surface of activated T cells around day 4-6 after activation through the TCR complex. Interaction of CD137 with its ligand, 4-1BBL, is reported to deliver a costimulatory signal important in the T-APC interaction. Recent data suggests CD317 is expressed on Tregs and may play a role in their proliferation. The monoclonal antibody 17B5 has strong antagonistic effect in in vitro functional assays.