CD133 Mouse anti-Human, APC, Clone: TMP4, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 17-1338-42

UNSPSC: 12000000

Code: NEW

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 12622059

Quantity Price
1 £ 192.42000000000002 / Each
EU Stock 2
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Description and Specification

Specification

Clone TMP4
Antigen CD133
Regulatory Status RUO
Isotype IgG1
Quantity 100 tests
Applications Flow Cytometry
Primary or Secondary Primary
Gene Alias AC133, Prominin-1
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Host Species Mouse
Concentration 5μL (0.125μg)/test
Conjugate APC
Species Reactivity Human
Format Conjugated
Monoclonal or Polyclonal Monoclonal
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.

The TMP4 monoclonal antibody reacts with human CD133 (Prominin-1), a 120kDa member of the pentaspan family of proteins, which also includes Prominin-2. Their expression is found within plasma membrane protrusions such as epithelial microvilli. CD133 can exist in a number of alternatively spliced isoforms, and the protein has several N-linked glycosylation sites: the occurrence of both may be tissue-dependent. Human CD133 was first identified as an epitope expressed on CD34+ hematopoietic progenitors. Although the ligand and function of CD133 remain unknown, it has since proven to be very useful as a marker for both stem cells and cancer stem cells. In addition to its expression on hematopoietic precursors, CD133 has been used to identify tumorigenic colon cancer stem cells, brain cancer stem cells, prostate cancer stem cells, in addition to others.

The binding of the TMP4 antibody does not block the binding of another anti-human CD133 antibody, EMK08 (cat. 12-1339) indicating that they recognize distinct epitopes.