CD131 Mouse anti-Human, PE, Clone: 1C1, eBioscience™
Mouse Monoclonal Antibody
Brand: Affymetrix eBioscience 12-1319-41
Code : NEW
Additional Details : Weight : 0.23750kg
DescriptionThe human IL-3, IL-5 and GM-CSF receptors are each composed of both unique a subunits and a common beta subunit. The a subunits are low affinity ligand binding proteins while the beta subunits do not themselves bind ligand, but are required for high affinity binding by the a subunits. In contrast, the mouse IL-3 receptor has two distinct beta subunits, one that functions only in IL-3 mediated cell signaling and a second that is shared with IL-5 and GM-CSF. The murine beta-subunits are 91% homologous at the amino acid level but only 56% homologous to the human beta subunit. Although neither the murine nor the human beta subunit contains tyrosine kinase domains, both activate tyrosine phosphorylation mediated signaling pathways.
|PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2|
|IL-3 Receptor beta, IL-3 RB, Cytokine receptor common subunit beta, GM-CSF IL-3 IL-5 receptor common beta subunit, CD antigen CD131, CSF2RB, Csf2rb, Aic2b, Csf2rb1, Il3rb1|
|4° C, store in dark, DO NOT FREEZE!|
For Research Use Only.