CD130 (gp130) Rat anti-Mouse, PE, Clone: KGP130, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-1302-80

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15536876

Quantity Price
1 £ 60.53 / 25µg
EU Stock 4
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Description and Specification

Specification

Species Reactivity Mouse
Isotype IgG2a
Host Species Rat
Monoclonal or Polyclonal Monoclonal
Concentration 0.2mg/mL
Regulatory Status RUO
Gene Alias gp130, IL-6 Receptor beta, IL-6RB
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Quantity 25μg
Format Conjugated
Clone KGP130
Antigen CD130 (gp130)
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Primary or Secondary Primary
Conjugate PE
Applications Flow Cytometry

The KGP130 monoclonal antibody reacts with mouse gp130, also known as CD130. gp130 is a 130 kD Type-I transmembrane glycoprotein containing a 597 amino acid extracellular domain, a single transmembrane domain, and a 277 amino acid cytoplasmic domain. gp130 is a subunit of several heterodimeric cell-surface receptors, including receptors for IL-6, IL-11, IL-27, Oncostatin M, and Leukemia Inhibitory Factor (LIF). The gp130 protein has also been found to exist in a soluble form, which is capable of inhibiting IL-6 signaling. gp130 is expressed mainly on T cells, monocytes, endothelial cells, activated B cells, and plasma cells, and is expressed at lower levels on most leukocytes and epithelial cells. In response to ligand binding, gp130 becomes tyrosine phosphorylated, leading to activation of several signaling pathways including the PI3 kinase, Ras-MAPk and Stat pathways.

Preincubation of mouse splenic T cells with IL-6 is capable of blocking the interaction of KGP130 with gp130, suggesting that the KGP130 binding site lies near the IL-6 interaction domain. Reactivity of KGP130 towards human gp130 has not been observed.