CD127 Rat anti-Mouse, Biotin, Clone: A7R34, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 13-1271-85

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15299709

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Description and Specification

Specification

Species Reactivity Mouse
Storage Requirements Store at 2-8°C. Do not freeze.
Format Conjugated
Applications Flow Cytometry
Isotype IgG2a
Regulatory Status RUO
Clone A7R34
Quantity 500μg
Monoclonal or Polyclonal Monoclonal
Conjugate Biotin
Antigen CD127
Host Species Rat
Primary or Secondary Primary
Gene Alias Interleukin-7 Receptor alpha
Concentration 0.5mg/mL
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer

The A7R34 monoclonal antibody reacts with mouse CD127, the high affinity alpha subunit of the mouse IL-7 receptor. IL-7 receptor alpha chain is expressed by immature B cells in the bone marrow, double-negative (CD4-CD8-), single-positive (CD4+ and CD8+), but not double-positive (CD4+CD8+) thymocytes. In the periphery, mature T cells express CD127 at low level. A7R34 inhibits binding of IL-7 to its receptor and has been used in in vivo and in vitro studies to elucidate the role of IL-7 in T and B cell development and activation. Binding of A7R34 blocks the binding of SB/199, another antibody which recognizes mouse CD127.