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CD127 Monoclonal Antibody (eBioRDR5), Super Bright™ 600, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
£159.00 - £359.00
Specifications
Antigen | CD127 |
---|---|
Clone | eBioRDR5 |
Concentration | 5 μL/Test |
Applications | Flow Cytometry |
Classification | Monoclonal |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
---|---|---|---|---|---|---|---|---|---|
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
15792486
|
Affymetrix eBioscience
63-1278-42 |
100 Tests |
£359.00
Pack of 100 |
Estimated Shipment: 06-06-2024 Log in to see stock. |
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15782486
|
Affymetrix eBioscience
63-1278-41 |
25 Tests |
This item is currently unavailable or has been discontinued. View the product page for possible alternatives. |
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Description
The eBioRDR5 monoclonal antibody reacts with human CD127 (Interleukin-7 Receptor alpha). CD127 complexes with CD132, also known as the common gamma chain (gamma c), to form the multi-functional IL-7 receptor (IL-7R). CD127 is a type I glycoprotein with a molecular weight of 75-80 kDa and is expressed by immature B cells through the early pre-B stage, by thymocytes during several stages of their development, and on most mature T cells, with transient down-regulation upon activation. Binding of IL-7 results in signal transduction which occurs through several tyrosine kinase pathways including the Jak/STAT pathway. IL-7 is indispensible for the development of lymphocytes, and the control of homeostatic proliferation of T-cells in the periphery. In addition, IL-7R signaling is know to be involved in the regulation of T cell receptor (TCR) locus rearrangement in gamma delta T cells. Interestingly, recently it has been demonstrated that CD127 expression is down-regulated on CD4+CD25+ regulatory T cells (T regs). While the co-expression of CD4 and CD25 has become widely used as an indicator of T regs, this method of identification may also include cells without suppressive activity.
CD127 Monoclonal antibody specifically detects CD127 in Human samples. It is validated for Flow Cytometry.Specifications
CD127 | |
5 μL/Test | |
Monoclonal | |
Liquid | |
RUO | |
P16871 | |
IgG1 κ | |
Affinity chromatography | |
Antibody |
eBioRDR5 | |
Flow Cytometry | |
Super Bright 600 | |
Mouse | |
Human | |
3575 | |
Primary | |
4° C, store in dark, DO NOT FREEZE! |
For Research Use Only