CD126 Rat anti-Mouse, PE-Cy7, Clone: D7715A7, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 25-1261-80

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15588466

Quantity Price
1 £ 84.99 / 25µg
Estimated Shipment date
from Supplier 04-05-2017
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Description and Specification

Specification

Host Species Rat
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material. This tandem dye is sensitive to photo-induced oxidation. Protect this vial from light during storage
Regulatory Status RUO
Isotype IgG2b
Primary or Secondary Primary
Quantity 25μg
Format Conjugated
Applications Flow Cytometry
Species Reactivity Mouse
Gene Alias Interleukin-6 Receptor alpha
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Monoclonal or Polyclonal Monoclonal
Conjugate PE-Cy7
Antigen CD126
Concentration 0.2mg/mL
Clone D7715A7

The monoclonal antibody D7715A7 recognizes mouse CD126, the IL-6 receptor α chain, a member of the Ig superfamily. CD126 can heterodimerize with CD130 (gp130) to form the high affinity IL-6 receptor. Once IL-6 is bound, signaling from the CD130 subunit is initiated and the receptor complex is internalized. The IL-6 receptor is also reported to exist as a soluble version, which bound to IL-6 acts in trans to signal. Expression is found on T lymphocytes in the periphery and during development in the thymus is restricted to SP populations, unlike gp130 which is expressed in all thymocytes. Additional expression has been shown on activated B lymphocytes, macrophages, granulocytes and CD34+ hematopoietic progenitor cells. The monoclonal antibody D7715A7 binding can be blocked addition of ligand (IL-6).