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CD126 Mouse anti-Human, PerCP-eFluor 710, Clone: 47.7G7.1F2, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 46-1269-42

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15599176

  • £182.87 / 100 tests


EU Stock 2
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Disclaimers:

For Research Use Only.


Description

Description

This monoclonal antibody 47.7G7.1F2 reacts with human CD126, also known as IL-6 receptor alpha. It associates with the gp130 chain to form the high-affinity receptor for IL-6. Although gp130 is ubiquitously expressed, CD126 is only found on mature T cells, activated B cells, macrophages, hepatocytes, and myeloma cells. Upon binding to IL-6, two heterotrimeric complexes of receptor and ligand associate into a hexamer and are then internalized, initializing Jak/STAT signaling pathways. IL-6 induces the proliferation and survival of T cells, Th2 differentiation, and acute-phase protein production in the liver. A soluble form of CD126 lacking the transmembrane domain is also present and can be generated by cleavage at the cell surface or alternative splicing. Soluble CD126 can bind IL-6 and activate cells expressing only gp130 through trans-presentation.
Specifications

Specifications

CD126
47.7G7.1F2
PerCP-eFluor 710
Conjugated
Murine
100 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry
5μL (0.06μg)/test
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Interleukin-6 Receptor alpha, IL-6Ra
IgG1
RUO
Primary
Human