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CD123 Monoclonal Antibody (6H6), FITC, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
£68.25 - £99.25
Specifications
| Antigen | CD123 |
|---|---|
| Clone | 6H6 |
| Concentration | 5 μL/Test |
| Applications | Flow Cytometry |
| Classification | Monoclonal |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
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15546486
|
Affymetrix eBioscience
11-1239-42 |
100 Tests |
£99.25
100 tests |
In Stock Log in to see stock. |
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|
15536486
|
Affymetrix eBioscience
11-1239-41 |
25 Tests |
This item is currently unavailable or has been discontinued. View the product page for possible alternatives. |
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Description
Description: The 6H6 monoclonal antibody reacts with human CD123, the alpha chain of the IL-3 receptor. This 60-70 kDa transmembrane protein binds to IL-3 with low affinity by itself, and when associated with CD131 (common beta chain) binds IL-3 with high affinity. CD123 is expressed by myeloid precursors, macrophages, dendritic cells, mast cells, basophils, and megakaryocytes. Applications Reported: This 6H6 antibody has been reported for use in flow cytometric analysis. Applications Tested: This 6H6 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 μL (0.25 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser. Filtration: 0.2 μm post-manufacturing filtered.
IL-3Ra (Interleukin-3 receptor subunit alpha) belongs to the type I cytokine receptor family and is a heterodimer with a unique alpha chain paired with the common beta (beta c or CDw131) subunit. IL-3Ra is responsible for the transmission of signal of Interleukin-3. IL-3Ra and IL-3Rb chain heterodimerization is induced by Interleukin-3, which is required for receptor activation but not high affinity binding. IL-3Ra is also reported that IL-3Ra subunits are overexpressed on acute myeloid leukemia (AML) blasts compared with normal hematopoietic cells and are thus potential targets for novel therapeutic agents.Specifications
| CD123 | |
| 5 μL/Test | |
| Monoclonal | |
| Liquid | |
| RUO | |
| P26951 | |
| IL3RA | |
| Primary | |
| 4° C, store in dark, DO NOT FREEZE! | |
| IL3RA |
| 6H6 | |
| Flow Cytometry | |
| FITC | |
| Mouse | |
| Human | |
| 3563 | |
| IgG1 κ | |
| Affinity chromatography | |
| Antibody |
For Research Use Only.