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CD122 Monoclonal Antibody (TM-b1 (TM-beta1)), PE, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

£180.00 - £286.00

Specifications

Antigen CD122
Clone TM-b1 (TM-beta1)
Concentration 0.2 mg/mL
Applications Flow Cytometry
Classification Monoclonal
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15208659
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Affymetrix eBioscience
12-1222-82
100 μg
£180.00
100µg
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Estimated Shipment: 03-04-2024
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15218659
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Affymetrix eBioscience
12-1222-83
200 μg
£286.00
200µg
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Estimated Shipment: 03-04-2024
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Description

Description

Description: The TM-b1 monoclonal antibody reacts with mouse CD122, the 90-110 kDa interleukin-2 receptor beta chain (IL-2R beta). CD122 is expressed by NK cells and some T cells in the periphery, and is upregulated by activation. CD122 associates with CD25 and CD132 (common gamma chain) to form the high affinity IL-2 receptor. High affinity binding of IL-2 to the IL-2 receptor is inhibited by the TM-b1 antibody. Applications Reported: The TM-b1 antibody has been reported for use in flow cytometric analysis. Applications Tested: This TM-b1 (TM-beta1) antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.125 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser. Filtration: 0.2 μm post-manufacturing filtered.

CD122 (Interleukin 2 receptor) is involved in T cell-mediated immune responses, primarily expressed in the hematopoietic system and is present in 3 forms. The low affinity form of CD122 is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from CD122. The protein encoded by the CD122 gene represents the beta subunit and is a type I membrane protein. Diseases associate with CD122 protein dysfunction include oligoarticular juvenile idiopathic arthritis and rheumatoid factor negative juvenile idiopathic arthritis.
Specifications

Specifications

CD122
0.2 mg/mL
Monoclonal
Liquid
RUO
P16297
Il2rb
Primary
4° C, store in dark, DO NOT FREEZE!
Il2rb
TM-b1 (TM-beta1)
Flow Cytometry
PE
Rat
Mouse
16185
IgG2b κ
Affinity chromatography
Antibody
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