CD122 Mouse anti-Human, PerCP-eFluor 710, Clone: TU27, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 46-1228-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15569176

Quantity Price
1 £ 72.77 / 25 tests
Estimated Shipment date
from Supplier 02-05-2017
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Description and Specification

Specification

Regulatory Status RUO
Conjugate PerCP-eFluor 710
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Clone TU27
Format Conjugated
Primary or Secondary Primary
Gene Alias Interleukin-2 Receptor beta, IL-2Rb, IL-2Rp75
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material. This tandem dye is sensitive to photo-induced oxidation. Protect this vial from light during storage
Antigen CD122
Quantity 25 tests
Host Species Mouse
Concentration 5μL (0.25μg)/test
Isotype IgG1
Species Reactivity Human
Monoclonal or Polyclonal Monoclonal
Applications Flow Cytometry

This TU27 monoclonal antibody reacts with human CD122, which is also known as interleukin-2 receptor beta (IL-2R beta). This receptor is expressed on NK cells, activated T cells, some B cells, monocytes, and T cell leukemias. CD122 can also be detected during early NK cell commitment. IL-2R beta associates with the IL-2R alpha (CD25) or IL-15R alpha and common gamma chain (CD132) to form the high affinity IL-2 and IL-15 receptors, respectively. By itself, this membrane receptor can bind IL-2, but with intermediate affinity. The binding of IL-2 results in internalization of the cytokine, tyrosine phosphorylation of IL-2Rβ, and activation of signaling cascades such as the JAK/STAT pathway.