CD11c Mouse, APC-eFluor 780, Clone: BU15, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 47-0128-42

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15579516

Quantity Price
1 £ 218.88 / 100 tests
EU Stock 5
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Description and Specification

Specification

Species Reactivity Canine, Cynomolgus, Human, Non-human primate
Antigen CD11c
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Applications Flow Cytometry
Regulatory Status RUO
Isotype IgG1
Primary or Secondary Primary
Gene Alias Integrin alpha-X, p150, CR4, Integrin aX, ITGAX
Host Species Mouse
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material. This tandem dye is sensitive to photo-induced oxidation. Protect this vial from light during storage
Clone BU15
Conjugate APC-eFluor 780
Format Conjugated
Quantity 100 tests
Concentration 5μL (0.125μg)/test
Monoclonal or Polyclonal Monoclonal

The BU15 monoclonal antibody reacts with canine, human, and non-human primate CD11c, the 150kDa integrin aX chain. CD11c non-covalently associates with beta2 integrin to form the CD11c/CD18 heterodimer. This complex is expressed on monocytes, granulocytes, macrophages, NK, dendritic cells, and subset of T and B lymphocytes. CD11c/CD18 binds to CD54, iC3b and fibrinogen and plays a role in leukocyte adhesive interactions. CD11c also binds complement fragment iC3b to mediate phagocytosis of opsonized particles.

The BU15 antibody has been reported to crossreact to cynomologus monkey. Moreover, this antibody has been reported to exhibit blocking activity. Crossblocking studies suggest that BU15 recognizes a different epitope from clone 3.9.