CD11c Mouse, APC, Clone: BU15, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 17-0128-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15567876

Quantity Price
1 £ 66.65 / 25 tests
Estimated Shipment date
from Supplier 08-05-2017
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Description and Specification

Specification

Regulatory Status RUO
Applications Flow Cytometry
Isotype IgG1
Monoclonal or Polyclonal Monoclonal
Conjugate APC
Concentration 5μL (0.06μg)/test
Antigen CD11c
Gene Alias Integrin alpha-X, p150, CR4, Integrin aX, ITGAX
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Primary or Secondary Primary
Clone BU15
Quantity 25 tests
Species Reactivity Canine, Cynomolgus, Human, Non-human primate
Format Conjugated
Host Species Mouse
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.

The BU15 monoclonal antibody reacts with canine, human, and non-human primate CD11c, the 150kDa integrin aX chain. CD11c non-covalently associates with ß2 integrin to form the CD11c/CD18 heterodimer. This complex is expressed on monocytes, granulocytes, macrophages, NK, dendritic cells, and subset of T and B lymphocytes. CD11c/CD18 binds to CD54, iC3b and fibrinogen and plays a role in leukocyte adhesive interactions. CD11c also binds complement fragment iC3b to mediate phagocytosis of opsonized particles.

The BU15 antibody has been reported to crossreact to cynomologus monkey. Moreover, this antibody has been reported to exhibit blocking activity. Crossblocking studies suggest that BU15 recognizes a different epitope from clone 3.9.