CD11c Mouse anti-Human, Clone: 118/A5, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-9761-82

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15577646

Quantity Price
1 £ 98.97 / 100µg
Estimated Shipment date
from Supplier 10-05-2017
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Description and Specification

Specification

Monoclonal or Polyclonal Monoclonal
Antigen CD11c
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Conjugate Unlabeled
Species Reactivity Human
Isotype IgG2b
Storage Requirements Store at 2-8°C.
Gene Alias Integrin alpha X
Regulatory Status RUO
Applications Immunohistochemistry (Formalin/Paraffin)
Applications Immunohistochemistry (Frozen)
Applications Microscopy
Clone 118/A5
Primary or Secondary Primary
Format Purified
Quantity 100μg
Concentration 0.5mg/mL
Host Species Mouse

The monoclonal antibody 118/A5 recognizes human CD11c, a 150 kD type I transmembrane protein which is also known as integrin alpha X. Integrins are heterodimeric integral membrane proteins made up of an alpha and a beta chain and are involved in cell adhesion. The CD11/CD18 adhesion molecules consist of three heterodimers sharing a common beta subunit (CD18) with a distinct alpha subunit (CD11a, CD11b, CD11c). The CD11c/CD18 complex is expressed on dendritic cells (highly expressed on type 1 myeloid DCs), monocytes, macrophages, granulocytes, NK cells, and subsets of T and B cells. CD11c is also expressed in hairy cell leukemias, acute nonlymphocytic leukemias, and some B-cell chronic lymphocytic leukemias. CD11c plays a role in adhesion and CTL killing through its interactions with CD54, iC3b and fibrinogen.