CD11b Rat anti-Mouse, Clone: M1/70, Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-0112-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15248377

Quantity Price
1 £ 91.11 / 100µg
Estimated Shipment date
from Supplier 04-05-2017
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Description and Specification

Specification

Storage Requirements Store at 2-8°C.
Applications Flow Cytometry
Applications Functional Assay
Applications Immunohistochemistry (Frozen)
Format Purified
Regulatory Status RUO
Species Reactivity Mouse
Gene Alias Integrin alpha M, ITGAM, Mac-1 alpha (Mac1A), Complement Receptor 3 alpha (CR3A)
Quantity 100μg
Primary or Secondary Primary
Antigen CD11b
Isotype IgG2b
Host Species Rat
Monoclonal or Polyclonal Monoclonal
Clone M1/70
Conjugate Unlabeled
Formulation aqueous buffer, no sodium azide

The M1/70 monoclonal antibody reacts with mouse CD11b, the 165-170kDa integrin αM. CD11b non-covalently associates with CD18 to form αMβ2 integrin (Mac-1) and binds to CD54 (ICAM-1), C3bi, and fibrinogen. Mac-1 is expressed by macrophages, NK cells, granulocytes, activated lymphocytes and mouse B-1 cells in the peritoneal cavity. M1/70 is also cross-reactive to human CD11b, and can be used for the detection of this antigen on human peripheral blood monocytes, granulocytes, and a subset of NK cells. Through interactions with its ligands, CD11b participates in adhesive cell interactions.