missing translation for 'onlineSavingsMsg'
Learn More

CD11b Mouse anti-Human, PE, Clone: CBRM1/5, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 12-0113-41

Code : NEW

Additional Details : Weight : 0.23750kg

 View more versions of this product

Product Code. 15586706

  • £66.65 / 25 tests


Call for latest availability
+44 (0)1509 555 500
Add to basket

Disclaimers:

For Research Use Only.


Description

Description

The CBRM1/5 monoclonal antibody reacts with an activation-specific epitope of human Mac-1. CBRM1/5 binds a subset of Mac-1 molecules on neutrophils and monocytes after stimulation with chemoattractants or phorbol esters but does not recognize Mac-1 on resting myeloid cells. Through interactions with its ligands, Mac-1 participates in adhesive cell interactions. The epitope recognized by this mAb localizes to the I domain on the α chain of Mac-1 very close to the ligand binding site in a region that is widely exposed. CBRM1/5 blocks Mac-1 dependent adhesion to fibrinogen and ICAM-1 and inhibits chemoattractant-stimulated adhesion of eosinophils to the Intercellular Adhesion Molecule-1 (ICAM-1). It should be noted that low level activation may occur during processing of freshly drawn blood. Therefore the CBRM1.5 antibody may exhibit some binding to Mac-1 in these unstimulated samples. However, higher levels of Mac-1 expression are observed in activated samples when compared to unstimulated cells.
Specifications

Specifications

CD11b
CBRM1/5
PE
Conjugated
Murine
25 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry
5μL (0.25μg)/test
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Integrin alpha M, Mac-1 alpha, Complement Receptor 3 alpha (CR3A)
IgG1
RUO
Primary
Human
Videos