missing translation for 'onlineSavingsMsg'
Learn More

CD117 (c-Kit) Rat anti-Mouse, Porcine, eFluor® 450, Clone: 2B8, eBioscience™

Rat Monoclonal Antibody

£52.25 - £133.00

Specifications

Antigen CD117 (c-kit)
Clone 2B8
Target Species Mouse, Porcine
Conjugate eFluor™ 450
Isotype IgG2b, kappa
View More Specs

Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15569706 View Documents Affymetrix eBioscience
48-1171-80
25 μg £52.25
25µg View alternative products
Save Up to 
»
Call for latest availability
+44 (0)1509 555 500
Please to purchase this item. Need a web account? Register with us today!
15579706 View Documents Affymetrix eBioscience
48-1171-82
100 μg £133.00
100µg View alternative products
Save Up to 
»
EU Stock 2 Please to purchase this item. Need a web account? Register with us today!
Description

Description

Please make sure that your instrument is capable of detecting this fluorochome. Excitation: 405 nm; Emission: 445 nm; Laser: Violet Laser. Filtration: 0.2 μm post-manufacturing filtered. c-Kit, also known as CD117 and stem cell factor receptor, is a 145 kDa transmembrane tyrosine kinase encoded by the c-Kit proto-oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. c-Kit mutations correlate with tumor growth and progression in a variety of cancers including mast cell disease, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma, and lung cancer. Phosphorylation at tyrosine 703 of c-Kit allows binding of Grb2 and activation of the Ras-Raf-ERK1&2 signaling pathway.
Specifications

Specifications

CD117 (c-kit)
Mouse, Porcine
IgG2b, kappa
Monoclonal
Liquid
Antibody
4° C, store in dark, DO NOT FREEZE!
2B8
eFluor™ 450
Flow Cytometry
Primary
Monoclonal
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
RUO

For Research Use Only.