CD115 (c-fms) Rat anti-Human, PE, Clone: 12-3A3-1B10, eBioscience™
Rat Monoclonal Antibody
Brand: Affymetrix eBioscience 12-1159-41
Code : NEW
Additional Details : Weight : 0.23750kg
DescriptionCD115 or Colony-Stimulating Factor-1 Receptor (CSF-1R) is expressed on cells committed to the monocyte lineage and osteoclasts. CSF-1R is a disulfide-linked homodimer, which upon binding of its ligand, CSF-1, undergoes tyrosine autophosphorylation and subsequently, phosphorylates other membrane-proximal downstream targets which results in cytoskeletal remodeling, gene transcription and protein translation. CSF-1R activation promotes the survival, proliferation and differentiation of mononuclear phagocytes and the spreading and motility of macrophages. In osteoclasts, CSF-1R synergizes with RANKL to regulate the differentiation of mononuclear phagocytes to osteoclasts.
|Store at 2-8°C. Do not freeze. Light-sensitive material.|
|aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer|
|CSF1R, colony-stimulating factor 1 Receptor|
For Research Use Only.