CD115 (c-fms) Rat anti-Human, PE, Clone: 12-3A3-1B10, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-1159-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15586856

Quantity Price
1 £ 78.88 / 25 tests
EU Stock 2
Add to basket


Description and Specification

Specification

Host Species Rat
Concentration 5μL (0.03μg)/test
Isotype IgG2a
Quantity 25 tests
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Conjugate PE
Monoclonal or Polyclonal Monoclonal
Antigen CD115 (c-fms)
Regulatory Status RUO
Applications Flow Cytometry
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Clone 12-3A3-1B10
Species Reactivity Human
Primary or Secondary Primary
Gene Alias CSF1R, colony-stimulating factor 1 Receptor
Format Conjugated

CD115 or Colony-Stimulating Factor-1 Receptor (CSF-1R) is expressed on cells committed to the monocyte lineage and osteoclasts. CSF-1R is a disulfide-linked homodimer, which upon binding of its ligand, CSF-1, undergoes tyrosine autophosphorylation and subsequently, phosphorylates other membrane-proximal downstream targets which results in cytoskeletal remodeling, gene transcription and protein translation. CSF-1R activation promotes the survival, proliferation and differentiation of mononuclear phagocytes and the spreading and motility of macrophages. In osteoclasts, CSF-1R synergizes with RANKL to regulate the differentiation of mononuclear phagocytes to osteoclasts.