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CD115 (c-fms) Rat anti-Human, PE, Clone: 12-3A3-1B10, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 12-1159-41

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15586856

  • £78.88 / 25 tests


EU Stock 2
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For Research Use Only.


Specifications

Description

CD115 or Colony-Stimulating Factor-1 Receptor (CSF-1R) is expressed on cells committed to the monocyte lineage and osteoclasts. CSF-1R is a disulfide-linked homodimer, which upon binding of its ligand, CSF-1, undergoes tyrosine autophosphorylation and subsequently, phosphorylates other membrane-proximal downstream targets which results in cytoskeletal remodeling, gene transcription and protein translation. CSF-1R activation promotes the survival, proliferation and differentiation of mononuclear phagocytes and the spreading and motility of macrophages. In osteoclasts, CSF-1R synergizes with RANKL to regulate the differentiation of mononuclear phagocytes to osteoclasts.
Description & Specifications

Specifications

CD115 (c-fms)
12-3A3-1B10
PE
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Rat
25 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry
5μL (0.03μg)/test
Conjugated
CSF1R, colony-stimulating factor 1 Receptor
IgG2a
RUO
Primary
Human