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CD115 (c-fms), PE, clone: 12-3A3-1B10, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 12-1159-42

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15596856

  • £192.92 / 100 tests


Estimated Shipment date
from Supplier 22-01-2018
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Disclaimers:

For Research Use Only.


Description

Description

Description: CD115 or Colony-Stimulating Factor-1 Receptor (CSF-1R) is expressed on cells committed to the monocyte lineage and osteoclasts. CSF-1R is a disulfide-linked homodimer, which upon binding of its ligand, CSF-1, undergoes tyrosine autophosphorylation and subsequently, phosphorylates other membrane-proximal downstream targets which results in cytoskeletal remodeling, gene transcription and protein translation. CSF-1R activation promotes the survival, proliferation and differentiation of mononuclear phagocytes and the spreading and motility of macrophages. In osteoclasts, CSF-1R synergizes with RANKL to regulate the differentiation of mononuclear phagocytes to osteoclasts.Applications Reported: This 12-3A3-1B10 antibody has been reported for use in flow cytometric analysis.Applications Tested: This 12-3A3-1B10 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood. This can be used at 5 μL (0.03 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

CD115
12-3A3-1B10
PE
Conjugated
Rat
100 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry
5μL (0.03μg)/test
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
CSF1R, colony-stimulating factor 1 Receptor
IgG2a
RUO
Primary
Human
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