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CD115 (c-fms) Rat anti-Human, Biotin, Clone: 12-3A3-1B10, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 13-1159-80

Code : Z2

Additional Details : Weight : 0.25000kg

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Product Code. 15289689

  • £60.53 / 25µg


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For Research Use Only.


Description

Description

CD115 or Colony-Stimulating Factor-1 Receptor (CSF-1R) is expressed on cells committed to the monocyte lineage and osteoclasts. CSF-1R is a disulfide-linked homodimer, which upon binding of its ligand, CSF-1, undergoes tyrosine autophosphorylation and subsequently, phosphorylates other membrane-proximal downstream targets which results in cytoskeletal remodeling, gene transcription and protein translation. CSF-1R activation promotes the survival, proliferation and differentiation of mononuclear phagocytes and the spreading and motility of macrophages. In osteoclasts, CSF-1R synergizes with RANKL to regulate the differentiation of mononuclear phagocytes to osteoclasts.
Specifications

Specifications

CD115 (c-fms)
12-3A3-1B10
Biotin
Conjugated
Rat
25μg
Store at 2-8°C. Do not freeze.
Monoclonal
Flow Cytometry
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
CSF1R, colony-stimulating factor 1 Receptor
IgG2a
RUO
Primary
Human
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