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CD115 (c-fms), Biotin, clone: 12-3A3-1B10, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 13-1159-80

Code : Z2

Additional Details : Weight : 0.25000kg

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Product Code. 15289689

  • £62.63 / 25µg


Estimated Shipment date
from Supplier 02-07-2018
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Description

Description

Description: CD115 or Colony-Stimulating Factor-1 Receptor (CSF-1R) is expressed on cells committed to the monocyte lineage and osteoclasts. CSF-1R is a disulfide-linked homodimer, which upon binding of its ligand, CSF-1, undergoes tyrosine autophosphorylation and subsequently, phosphorylates other membrane-proximal downstream targets which results in cytoskeletal remodeling, gene transcription and protein translation. CSF-1R activation promotes the survival, proliferation and differentiation of mononuclear phagocytes and the spreading and motility of macrophages. In osteoclasts, CSF-1R synergizes with RANKL to regulate the differentiation of mononuclear phagocytes to osteoclasts.Applications Reported: This 12-3A3-1B10 antibody has been reported for use in flow cytometric analysis.Applications Tested: This 12-3A3-1B10 antibody has been tested by flow cytometric analysis of normal human peripheral blood. This can be used at less than or equal to 0.06 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

CD115 (c-fms)
Monoclonal
0.5mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
P07333
C-FMS, CD115, CSFR, FIM2, FMS
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry
12-3A3-1B10
Biotin
CSF1R
Conjugated
CSF1R
IgG2a, kappa
25μg
Store at 2-8°C. Do not freeze.
Primary
1436
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