CD115 (c-fms) Rat anti-Human, Biotin, Clone: 12-3A3-1B10, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 13-1159-80

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15289689

Quantity Price
1 £ 60.53 / 25µg
Estimated Shipment date
from Supplier 08-05-2017
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Description and Specification

Specification

Host Species Rat
Regulatory Status RUO
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Gene Alias CSF1R, colony-stimulating factor 1 Receptor
Quantity 25μg
Monoclonal or Polyclonal Monoclonal
Isotype IgG2a
Storage Requirements Store at 2-8°C. Do not freeze.
Conjugate Biotin
Species Reactivity Human
Concentration 0.5mg/mL
Clone 12-3A3-1B10
Format Conjugated
Primary or Secondary Primary
Antigen CD115 (c-fms)
Applications Flow Cytometry

CD115 or Colony-Stimulating Factor-1 Receptor (CSF-1R) is expressed on cells committed to the monocyte lineage and osteoclasts. CSF-1R is a disulfide-linked homodimer, which upon binding of its ligand, CSF-1, undergoes tyrosine autophosphorylation and subsequently, phosphorylates other membrane-proximal downstream targets which results in cytoskeletal remodeling, gene transcription and protein translation. CSF-1R activation promotes the survival, proliferation and differentiation of mononuclear phagocytes and the spreading and motility of macrophages. In osteoclasts, CSF-1R synergizes with RANKL to regulate the differentiation of mononuclear phagocytes to osteoclasts.