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CD114 (G-CSFR) Mouse anti-Human, PerCP-eFluor 710, Clone: LMM741, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 46-1149-41

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15529176

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Disclaimers:

For Research Use Only.


Description

Description

This LMM741 monoclonal antibody reacts with human CD114, which is also known as granulocyte colony-stimulating factor receptor (G-CSFR). A type I hematopoietin cytokine receptor, CD114 is expressed on granulocytes such as neutrophils, myeloid cells, monocytes, and leukemic cells. This receptor is absent from lymphocytes, erythrocytes, and eosinophils. CD114 can also be detected on non-hematopoietic cells, including neurons, endothelial cells, and cardiomyocytes. Studies demonstrate that expression of CD114 can be downregulated by LPS, TNF, phorbol ester, and G-CSF itself. Binding of G-CSF binding induces homodimerization of the receptor that activates signaling transduction (e.g., the JAK/STAT and Erk1/2 pathways) to mediate cell proliferation, survival, and differentiation.
Specifications

Specifications

CD114 (G-CSFR)
LMM741
PerCP-eFluor™ 710
Conjugated
Murine
25 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry
5μL (0.25μg)/test
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Granulocyte colony-stimulating factor receptor, CSF3R
IgG1
RUO
Primary
Human