CD114 (G-CSFR) Mouse anti-Human, PerCP-eFluor 710, Clone: LMM741, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 46-1149-41

25TEST Anti-Human CD114 (G-CSFR) PerCP-eFluor 710

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15529176

Quantity Price
1 £ 124.4 / 25 tests
Estimated Shipment date
from Supplier 22-02-2017
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Description and Specification

Specification

Antigen CD114 (G-CSFR)
Format Conjugated
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Gene Alias Granulocyte colony-stimulating factor receptor, CSF3R
Host Species Mouse
Applications Flow Cytometry
Isotype IgG1
Quantity 25 tests
Regulatory Status RUO
Species Reactivity Human
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Clone LMM741
Concentration 5μL (0.25μg)/test
Conjugate PerCP-eFluor 710

This LMM741 monoclonal antibody reacts with human CD114, which is also known as granulocyte colony-stimulating factor receptor (G-CSFR). A type I hematopoietin cytokine receptor, CD114 is expressed on granulocytes such as neutrophils, myeloid cells, monocytes, and leukemic cells. This receptor is absent from lymphocytes, erythrocytes, and eosinophils. CD114 can also be detected on non-hematopoietic cells, including neurons, endothelial cells, and cardiomyocytes. Studies demonstrate that expression of CD114 can be downregulated by LPS, TNF, phorbol ester, and G-CSF itself. Binding of G-CSF binding induces homodimerization of the receptor that activates signaling transduction (e.g., the JAK/STAT and Erk1/2 pathways) to mediate cell proliferation, survival, and differentiation.