CD106 (VCAM-1) Rat anti-Mouse, PE, Clone: 429, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-1061-82

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15596846

Quantity Price
1 £ 170.59 / 100µg
Estimated Shipment date
from Supplier 03-05-2017
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Description and Specification

Specification

Host Species Rat
Conjugate PE
Primary or Secondary Primary
Concentration 0.2mg/mL
Antigen CD106 (VCAM-1)
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Regulatory Status RUO
Species Reactivity Mouse
Gene Alias VCAM1, vascular cell adhesion molecule-1
Applications Flow Cytometry
Format Conjugated
Clone 429
Isotype IgG2a
Quantity 100μg

The 429 monoclonal antibody reacts with mouse CD106 (Vascular Cell Adhesion Molecule-1, VCAM-1), a 110kDa transmembrane glycoprotein expressed by myeloid lineage and bone marrow stromal cells. Endothelial cells constitutively express low levels of CD106 and upregulate it upon cytokine stimulation. CD106 binds to integrin alpha4 beta1 (VLA-4, CD49d/CD29) and Integrin a4b7 (LPAM-1) and these interactions in the bone marrow and thymus are important for early lymphocyte and myeloid development. Cytokine-mediated upregulation of CD106 on endothelial cells suggests a role for this antigen in the inflammatory response.