CD106 (VCAM-1) Rat anti-Mouse, FITC, Clone: 429, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 11-1061-81

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15208169

Quantity Price
1 £ 48.31 / 50µg
EU Stock 2
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Description and Specification

Specification

Quantity 50μg
Format Conjugated
Conjugate FITC
Isotype IgG2a
Host Species Rat
Concentration 0.5mg/mL
Monoclonal or Polyclonal Monoclonal
Primary or Secondary Primary
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Species Reactivity Mouse
Clone 429
Applications Flow Cytometry
Gene Alias VCAM1, vascular cell adhesion molecule-1
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Regulatory Status RUO
Antigen CD106 (VCAM-1)

The 429 monoclonal antibody reacts with mouse CD106 (Vascular Cell Adhesion Molecule-1, VCAM-1), a 110kDa transmembrane glycoprotein expressed by myeloid lineage and bone marrow stromal cells. Endothelial cells constitutively express low levels of CD106 and upregulate it upon cytokine stimulation. CD106 binds to integrin α4β1 (VLA-4, CD49d/CD29) and Integrin a4b7 (LPAM-1) and these interactions in the bone marrow and thymus are important for early lymphocyte and myeloid development. Cytokine-mediated upregulation of CD106 on endothelial cells suggests a role for this antigen in the inflammatory response.