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CD106 (VCAM-1) Rat anti-Mouse, FITC, Clone: 429, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 11-1061-85

UNSPSC : 12352200

Code : Z2

Additional Details : Weight : 0.25000kg

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Product Code. 15228169

This item has been discontinued and is no longer available. View the product for possible alternatives or contact our Product Support team on 01509 555888 for assistance

Disclaimers:

For Research Use Only.


Specifications

Description

The 429 monoclonal antibody reacts with mouse CD106 (Vascular Cell Adhesion Molecule-1, VCAM-1), a 110kDa transmembrane glycoprotein expressed by myeloid lineage and bone marrow stromal cells. Endothelial cells constitutively express low levels of CD106 and upregulate it upon cytokine stimulation. CD106 binds to integrin α4β1 (VLA-4, CD49d/CD29) and Integrin a4b7 (LPAM-1) and these interactions in the bone marrow and thymus are important for early lymphocyte and myeloid development. Cytokine-mediated upregulation of CD106 on endothelial cells suggests a role for this antigen in the inflammatory response.
Description & Specifications

Specifications

CD106 (VCAM-1)
429
FITC
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Rat
500μg
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry
0.5mg/mL
Conjugated
VCAM1, vascular cell adhesion molecule-1
IgG2a
RUO
Primary
Murine