CD106 (VCAM-1) Rat anti-Mouse, eFluor 660, Clone: 429, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 50-1061-80

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15311880

Quantity Price
1 £ 58.09 / 25µg
Estimated Shipment date
from Supplier 05-05-2017
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Description and Specification

Specification

Quantity 25μg
Regulatory Status RUO
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Isotype IgG2a
Species Reactivity Mouse
Concentration 0.2mg/mL
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Applications Flow Cytometry
Gene Alias VCAM1, vascular cell adhesion molecule-1
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Antigen CD106 (VCAM-1)
Format Conjugated
Host Species Rat
Conjugate eFluor 660
Clone 429

The 429 monoclonal antibody reacts with mouse CD106 (Vascular Cell Adhesion Molecule-1, VCAM-1), a 110kDa transmembrane glycoprotein expressed by myeloid lineage and bone marrow stromal cells. Endothelial cells constitutively express low levels of CD106 and upregulate it upon cytokine stimulation. CD106 binds to integrin alpha4 beta1 (VLA-4, CD49d/CD29) and Integrin a4b7 (LPAM-1) and these interactions in the bone marrow and thymus are important for early lymphocyte and myeloid development. Cytokine-mediated upregulation of CD106 on endothelial cells suggests a role for this antigen in the inflammatory response.