CD106 (VCAM-1) Rat anti-Mouse, eFluor 660, Clone: 429, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 50-1061-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15321880

Quantity Price
1 £ 131.46 / 100µg
Estimated Shipment date
from Supplier 03-04-2017
Add to basket


Description and Specification

Specification

Regulatory Status RUO
Species Reactivity Mouse
Antigen CD106 (VCAM-1)
Isotype IgG2a
Monoclonal or Polyclonal Monoclonal
Conjugate eFluor 660
Gene Alias VCAM1, vascular cell adhesion molecule-1
Clone 429
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Applications Flow Cytometry
Primary or Secondary Primary
Format Conjugated
Concentration 0.2mg/mL
Quantity 100μg
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Host Species Rat

The 429 monoclonal antibody reacts with mouse CD106 (Vascular Cell Adhesion Molecule-1, VCAM-1), a 110kDa transmembrane glycoprotein expressed by myeloid lineage and bone marrow stromal cells. Endothelial cells constitutively express low levels of CD106 and upregulate it upon cytokine stimulation. CD106 binds to integrin alpha4 beta1 (VLA-4, CD49d/CD29) and Integrin a4b7 (LPAM-1) and these interactions in the bone marrow and thymus are important for early lymphocyte and myeloid development. Cytokine-mediated upregulation of CD106 on endothelial cells suggests a role for this antigen in the inflammatory response.