CD106 (VCAM-1) Rat anti-Mouse, eFluor 450, Clone: 429, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 48-1061-80

Product Code. 15301750

Disclaimers:

For Research Use Only.

Description

The 429 monoclonal antibody reacts with mouse CD106 (Vascular Cell Adhesion Molecule-1, VCAM-1), a 110kDa transmembrane glycoprotein expressed by myeloid lineage and bone marrow stromal cells. Endothelial cells constitutively express low levels of CD106 and upregulate it upon cytokine stimulation. CD106 binds to integrin α₄β₁ (VLA-4, CD49d/CD29) and Integrin a4b7 (LPAM-1) and these interactions in the bone marrow and thymus are important for early lymphocyte and myeloid development. Cytokine-mediated upregulation of CD106 on endothelial cells suggests a role for this antigen in the inflammatory response.

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Specifications

• Antigen: CD106 (VCAM-1)
• Clone: 429
• Conjugate: eFluor 450
• Format: Conjugated
• Host Species: Rat
• Quantity: 25μg
• Storage Requirements: Store at 2-8°C. Do not freeze. Light-sensitive material.
• Monoclonal or Polyclonal: Monoclonal

• Applications: Flow Cytometry
• Concentration: 0.2mg/mL
• Formulation: aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
• Gene Alias: VCAM1, vascular cell adhesion molecule-1
• Isotype: IgG2a
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Murine